Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Feb 28:3:10.
doi: 10.4103/2156-7514.107995. Print 2013.

Mixed adenoneuroendocrine carcinoma of cecum: a rare entity

Aditi Jain  1 , Saurabh Singla, K S Jagdeesh, H Y Vishnumurthy
Affiliations
Case Reports

Mixed adenoneuroendocrine carcinoma of cecum: a rare entity

Aditi Jain et al. J Clin Imaging Sci. .

Abstract

Mixed adenoneuroendocrine carcinoma of cecum (MANEC) was first reported by Cardier in 1924. These tumors are thought to arise from multi-potential stem cells, which have differentiated bidirectionally. Location of the tumor influences the treatment and outcome. We report a rare case of MANEC where the patient presented with abdominal pain and distension. Imaging revealed an ileo colic intussusception with the lead point being a MANEC.

Keywords: Cecum; composite tumor; mixed adenoneuroendocrine carcinoma.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

None
Aditi Jain
Figure 1
Figure 1
Contrast enhanced computed tomography of abdomen and pelvis (axial section) shows A. Enhancing Intraluminal caecal mass with caecal wall thickening. B. Adjacent necrotic mesentric nodes and C. Dilated small bowel loops with few of them having thickened walls.
Figure 2
Figure 2
Contrast enhanced computed tomography of abdomen and pelvis (axial section) reveals thickened ileum loop extending into the cecum (arrow).
Figure 3
Figure 3
Hematoxylin and eosin stained sample (a) at ×10 and (b) at ×40 demonstrate large monomorphic tumor cells having large round cell nucleus and abundant eosinophilic cytoplasm (seen arranged in cords and nests in Figure 3a).
Figure 4
Figure 4
Hematoxylin and eosin stained tissue (a) at ×10 and (b) at ×40 show glandular formation (arrow) amounting to >30% of the tumor.
Figure 5
Figure 5
Hematoxylin and eosin stained tissue at ×10 shows tumor cells surrounded by focal lymphocyte response.
See this image and copyright information in PMC

References

    1. Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: A review of nomenclature, grading, and staging systems. Pancreas. 2010;39:707–12. - PubMed
    1. Ramage JK, Davies AH, Ardill J, Bax N, Caplin M, Grossman A, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumors. Gut. 2005;54:iv1–16. - PMC - PubMed
    1. La Rosa S, Marando A, Sessa F, Capella C. Mixed adenoneuroendocrine carcinoma (MANECs) of the gastrointestinal tract: An update. Cancers. 2012;4:11–30. - PMC - PubMed
    1. Suttmann H. A mixed adenocarcinoma and neuroendocrine carcinoma of the rectum associated with an adenocarcinoma of the prostate as a second primary malignancy: Report of a case. Electron J Pathol Histol. 2003;9:32–8.
    1. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO Classification of Tumours of the Digestive System. 4th ed. Lyon, France: WHO, International Agency for Research on Cancer; 2010. Nomenclature and classification of neuroendocrine neoplasms of the digestive system; p. 13.

Publication types