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Comparative Study
. 1990 May;34(5):918-21.
doi: 10.1128/AAC.34.5.918.

Berberine derivatives as antileishmanial drugs

J L Vennerstrom  1 , J K Lovelace, V B Waits, W L Hanson, D L Klayman
Affiliations
Comparative Study

Berberine derivatives as antileishmanial drugs

J L Vennerstrom et al. Antimicrob Agents Chemother. 1990 May.

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis.

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