Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul;108(1):42-6.
doi: 10.1002/jso.23341. Epub 2013 Apr 22.

Tumor budding as a useful prognostic marker in T1-stage squamous cell carcinoma of the esophagus

Hitoshi Teramoto  1 , Masahiko Koike, Chie Tanaka, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Michitaka Fujiwara, Yasuhiko Suzuki, Yasuhiro Kodera
Affiliations
Free PMC article

Tumor budding as a useful prognostic marker in T1-stage squamous cell carcinoma of the esophagus

Hitoshi Teramoto et al. J Surg Oncol. 2013 Jul.
Free PMC article

Abstract

Background: Establishing a new prognostic factor for early-stage cancer may seem difficult due to the small number of disease-specific deaths. Tumor budding has been recognized as a useful microscopic finding reflecting biological activity of the tumor.

Methods: Tumor budding stand for isolated single cancer cells and cell clusters scattered beyond the tumor margin at the invasive front. It was searched for in the resected esophagus with T1 squamous cell carcinoma (SCC), and the correlation between the tumor budding, patient survival, and various pathologic factors were analyzed to verify whether tumor budding is a prognostic factor in superficial esophageal cancer.

Results: Seventy-nine patients undergoing curative esophagectomy were assigned to frequent (n = 29) and rare (n = 50) groups according to the microscopically observed frequency of tumor budding in the tumor. Three-year survival rates after esophagectomy were 48.8% for the frequent group and 94.5% for the rare group. Multivariate analysis using the Cox proportional hazards model identified this morphological variable as a significant independent prognostic factor.

Conclusions: Tumor budding reflects the biological activity of the tumor and may be a useful prognostic indicator even in early-stage SCC of esophagus.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a,b: The configuration of a lesion with tumor budding in T1 esophageal cancer. (many tumor budding foci, showing by arrows; a, 100×: b, 400×). c,d: Tumor budding in an EMR specimen of T1 esophageal cancer (tumor budding foci, showing by arrows a, 5×; b, 400×).
Fig. 2
Fig. 2
Cumulative curves for survival after esophagectomy in patients with frequent (n = 29) and rare (n = 50) budding. The difference in survival between groups was significant (P < 0.001).
See this image and copyright information in PMC

References

    1. Eguchi T, Nakanishi Y, Shimoda T, et al. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: Analysis of 464 surgically resected cases. Mod Pathol. 2006;19:475–480. - PubMed
    1. Kodama M, Kakegawa T: Treatment of superficial cancer of the esophagus: A summary of responses to a questionnaire on superficial cancer of the esophagus in Japan. Surgery. 1998;123:432–439. - PubMed
    1. Tajima Y, Nakanishi Y, Ochiai A, et al. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma: Analysis of 240 surgically resected tumors. Cancer. 2000;88:1285–1293. - PubMed
    1. Inoue H, Tani M, Nagai K, et al. Treatment of esophageal and gastric tumors. Endoscopy. 1999;31:47–55. - PubMed
    1. Hase K, Shatney C, Johnson D, et al. Prognostic value of tumor “budding” in patients with colorectal cancer. Dis Colon Rectum. 1993;36:627–635. - PubMed

MeSH terms