Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Jul;23(7):866-7.
doi: 10.1038/cr.2013.57. Epub 2013 Apr 23.

miRNAGE-34 induces cardiac damAGE

Costanza Emanueli  1 , Thomas Thum
Affiliations
Comment

miRNAGE-34 induces cardiac damAGE

Costanza Emanueli et al. Cell Res. 2013 Jul.

Abstract

Small non-coding microRNAs (miRNAs, miRs) regulate gene expression in virtually all cells, and they have been implicated in cardiovascular disease and aging. In a paper recently published in Nature, miR-34a was identified as an aging-associated apoptotic and overall damaging factor for the heart.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic diagrams of the effects of microRNA-34 (miR-34) inhibition in the aged or ischemic heart. PNUTS, protein phosphatase 1 nuclear-targeting subunit (miR-34 target gene); TRF2, telomeric protein telomere repeat factor 2.
See this image and copyright information in PMC

Comment on

  • MicroRNA-34a regulates cardiac ageing and function.
    Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. Boon RA, et al. Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20. Nature. 2013. PMID: 23426265

References

    1. Boon RA, Iekushi K, Lechner S, et al. Nature. 2013. pp. 107–110. - PubMed
    1. Gullo C, Au M, Feng G, et al. Biochim Biophys Acta. 2006. pp. 223–234. - PubMed
    1. Jazbutyte V, Fiedler J, Kneitz S, et al. Age(Dordr)201335747–762. - PMC - PubMed
    1. Iekushi K, Seeger F, Assmus B, et al. Circulation. 2012. pp. 1765–1773.pp. S1–S7. - PubMed
    1. Bernardo BC, Gao XM, Winbanks CE, et al. Proc Natl Acad Sci USA. 2012. pp. 17615–17620. - PMC - PubMed