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Review
. 2013 Jul;26(4):464-9.
doi: 10.1111/pcmr.12109. Epub 2013 May 28.

Targeting melanoma by small molecules: challenges ahead

Rizwan Haq  1 , David E Fisher
Affiliations
Review

Targeting melanoma by small molecules: challenges ahead

Rizwan Haq et al. Pigment Cell Melanoma Res. 2013 Jul.

Abstract

Significant progress has been made in targeting melanoma using small molecule inhibitors, but challenges remain. Here we describe the history of screening approaches in melanoma and their limitations. We propose several approaches to refine our screening models to enhance the discovery process. It is hoped that this discussion will stimulate further improvements in our development of small molecules inhibitors for treatment of melanoma patients.

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