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. 2013 Jul;57(7):3415-9.
doi: 10.1128/AAC.02383-12. Epub 2013 Apr 22.

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

Mariama Issaka  1 , Adamou Salissou, Ibrahim Arzika, Julia Guillebaud, Abani Maazou, Sabine Specht, Halima Zamanka, Thierry Fandeur
Affiliations

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

Mariama Issaka et al. Antimicrob Agents Chemother. 2013 Jul.

Abstract

Little is known about resistance of Plasmodium falciparum to antimalarials in Sahelian countries. Here we investigated the drug susceptibilities of fresh isolates collected in Niger post-deployment of artemisinin-based combination therapies (ACTs). We found that the parasites remained highly susceptible to new (dihydroartemisinin, lumefantrine, pyronaridine, and piperaquine) and conventional (amodiaquine and chloroquine) antimalarial drugs. The introduction of ACTs in 2005 and their further deployment nationwide have therefore not resulted in a decrease in P. falciparum susceptibilities to these antimalarials.

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Figures

Fig 1
Fig 1
ApoI restriction digestion of Pfcrt fragments and genotype distribution among Nigerien isolates. Sample identification numbers (#ID) and the IC50 of CQ are indicated. For each sample, the first and second lanes correspond to undigested and ApoI-digested PCR products, respectively. M, SmartLadder SF (Eurogentec).
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