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Review
. 2013 May;36(5):1413-21.
doi: 10.2337/dc12-2211.

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

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Review

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Paul W Franks et al. Diabetes Care. 2013 May.
No abstract available

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Figures

Figure 1
Figure 1
The future of research on stratified diabetes medicine: a systems epidemiology approach to the discovery of interactions between the exposome (all nongenetic elements to which we are exposed) and the quantifiable elements of the human physiome.
Figure 2
Figure 2
The evolving landscape of established type 2 diabetes-associated genetic loci. Effect estimates and list of loci are adapted from reference . Variants in CCND2 and GIPR (not shown in Fig.) have sex-heterogeneous effects, with the former having a larger effect in males and the latter in females (21). *This locus was initially associated with type 2 diabetes by Renström et al. (67).

References

    1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047–1053 - PubMed
    1. Ayach BB, Korda H. Type 2 diabetes epidemic in First Nations people of Canada. Ethn Dis 2010;20:300–303 - PubMed
    1. King H, Rewers M, WHO Ad Hoc Diabetes Reporting Group Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 1993;16:157–177 - PubMed
    1. Franks PW, Looker HC, Kobes S, et al. Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes 2006;55:460–465 - PubMed
    1. Schulz LO, Bennett PH, Ravussin E, et al. Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care 2006;29:15866–1871 - PubMed

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