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. 2013 Feb 28;13(2):e8611.
doi: 10.5812/hepatmon.8611. Print 2013 Feb.

Predictors of Chronic Hepatitis C Evolution in HIV Co-Infected Patients From Romania

Camelia Sultana  1 , Simona Manuela Erscoiu, Camelia Grancea, Emanoil Ceausu, Simona Ruta
Affiliations

Predictors of Chronic Hepatitis C Evolution in HIV Co-Infected Patients From Romania

Camelia Sultana et al. Hepat Mon. .

Abstract

Background: Due to a recent alarming increase in the number of HIV-HCV co-infected patients in Romania.

Objectives: A cross sectional study was conducted to assess the baseline predictors of liver disease evolution.

Patients and methods: 83 HIV-HCV co-infected patients, untreated for HCV infection, were evaluated for viral replication, liver fibrosis (estimated by a noninvasive marker - FIB4), and plasma levels of IP-10 (interferon-gamma inducible protein 10) - a cytokine associated with an unfavorable outcome of HCV infection.

Results: The median value for HCV viral load was high (6.3 log10 IU/mL), 98.8% of the patients were infected with HCV genotype 1. Although 53% of the patients received antiretroviral therapy (cART), only 31.8% of these achieved undetectable HIV levels. HCV viral load was significantly higher in patients with AIDS (6.4 vs. 6.1 log10IU/mL; P = 0.04), and in those naïve for cART (6.5 vs. 5.9 log10 IU/mL; P = 0.04). Severe fibrosis was directly correlated with immunosupression (56% vs. 17.4%, P = 0.03), HCV replication (6.1 vs. 4.9 log10IU/mL P = 0.008), and IP-10 median values (312 vs. 139 pg/ml, P=0.008). A serum IP-10 level higher than 400 pg/mL was significantly associated with FIB-4 median values (4.09 vs. 1.7, P = 0.004), HCV viral load (6.4 vs. 6.1 log10 IU/mL, P = 0.02) and ALT level (206.8 vs. 112.4 IU/L, P = 0.05).

Conclusions: An important part of the HIV-HCV co-infected patients had negative baseline predictors for the evolution of HCV infection; their therapeutical management must be conducted with special attention towards adherence and potential overlapping drug toxicities. High concentrations of plasma IP-10 are reliable markers for the severity of liver disease.

Keywords: Biological Markers; Coinfection; Romania.

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Figures

Figure 1
Figure 1. Correlation Between cART Treatment, FIB-4 Index and Plasma ALT Levels
See this image and copyright information in PMC

References

    1. Soriano V, Puoti M, Sulkowski M, Cargnel A, Benhamou Y, Peters M, et al. Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel. AIDS. 2007;21(9):1073–89. doi: 10.1097/QAD.0b013e3281084e4d. - DOI - PubMed
    1. Chung RT, Andersen J, Volberding P, Robbins GK, Liu T, Sherman KE, et al. Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. N Engl J Med. 2004;351(5):451–9. doi: 10.1056/NEJMoa032653. - DOI - PMC - PubMed
    1. Carrat F, Bani-Sadr F, Pol S, Rosenthal E, Lunel-Fabiani F, Benzekri A, et al. Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trial. JAMA. 2004;292(23):2839–48. doi: 10.1001/jama.292.23.2839. - DOI - PubMed
    1. Operskalski EA, Kovacs A. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Curr HIV/AIDS Rep. 2011;8(1):12–22. doi: 10.1007/s11904-010-0071-3. - DOI - PMC - PubMed
    1. Compartment for Monitoring and Evaluation of HIV/AIDS infection in Romania. [cited 30 June];2012 Available from: http://www.cnlas.ro/images/doc/romania_30iunie2012.pdf.

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