doi: 10.1021/ol4008876.
Epub 2013 Apr 24.
Arylation of aldehyde homoenolates with aryl bromides
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- PMID: 23614790
- DOI: 10.1021/ol4008876
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Arylation of aldehyde homoenolates with aryl bromides
Org Lett.
.
Abstract
A mild palladium catalyzed coupling of reactive aldehyde homoenolates with aryl bromides is described. Aldehyde homoenolates are generated by ring opening of cyclopropanols via a C-C cleavage step. The coupling generates aldehyde products at room temperature in 59-93% yield.
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