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. 2013 May 1;40(3):E126-34.
doi: 10.1188/13.ONF.E126-E134.

Frailty in older breast cancer survivors: age, prevalence, and associated factors

Jill A Bennett  1 , Kerri M Winters-Stone, Jessica Dobek, Lillian M Nail
Affiliations

Frailty in older breast cancer survivors: age, prevalence, and associated factors

Jill A Bennett et al. Oncol Nurs Forum. .

Abstract

Purpose/objectives: To describe frailty and associated factors in breast cancer survivors (BCSs) and evaluate whether BCSs are frail at an earlier age than female participants from in two large epidemiological studies.

Design: Descriptive, cross-sectional.

Setting: School of Nursing at Oregon Health and Science University.

Sample: 216 BCSs aged 53-87 years who were a mean 5-7 years post-treatment and not currently participating in exercise.

Methods: Performance tests, clinical measures, and self-reported questionnaires provided baseline data on five criteria for frailty.

Main research variables: Frailty was defined as meeting three of the five criteria of the frailty phenotype: shrinking, exhaustion, low activity, slowness, and weakness. Data were compared to published data from women in the Cardiovascular Health Study (CHS) and Women's Health and Aging Study (WHAS).

Findings: Eighteen percent of BCSs aged 70-79 years were frail compared to 11% of women of the same age in the CHS and WHAS. Frailty was more common at a younger age in BCSs, and more BCSs were frail in all age groups compared to women in the CHS study until about age 80 years, when prevalence of frailty was similar in the two groups. Fifty percent of BCSs were classified as prefrail because they met one or two of the five frailty criteria. Higher body mass index increased the odds of frailty, and higher physical activity decreased the odds of frailty (odds ratio [OR] = 1.12, p = 0.003, and OR = 0.99, p = 0.000, respectively).

Conclusions: Frailty and prefrailty may be common in BCSs and may occur at an earlier age than in adults without a history of breast cancer.

Implications for nursing: Nurses should be alert to prefrailty or frailty at a younger age in BCSs. Awareness and early intervention may delay or prevent frailty.

Knowledge translation: BCSs may be frail even when they are not yet considered older adults. Prefrailty in BCSs is important to recognize because it suggests impending frailty that could lead to reduced physical functioning or poor health. Prefrailty and frailty could be assessed in BCSs aged 50 years and older in a clinical setting using a few questions about weight, fatigue, and activity levels, in addition to simple tests of walking speed and grip strength, if warranted.

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Figures

Figure 1
Figure 1
Comparison of prefrailty and frailty among BCS, women in WHAS and women in CHS. aBCS aged 70–79 years Notes: BCS = Breast cancer survivors; WHAS = Women’s Health and Aging Study; CHS = Cardiovascular Health Study; BMI = body mass index WHAS and CHS portion of table previously published and used with permission from Oxford University Press. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P et al. Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006;61(3):262–6.
Figure 2
Figure 2
Proportion of frailty and prefrailty by age in breast cancer survivors and women in the Cardiovascular Health Study Note: Data in five-year increments was not available for prefrail women in CHS or for frail or prefrail women in Women’s Health and Aging Study (WHAS) Abbreviations: BCS: Breast cancer survivors; CHS: Cardiovascular Health Study Prefrail: meets 1–2 of 5 frailty criteria; Frail: meets 3 of 5 frailty criteria an=6 BCS aged 80–84, n=3 BCS aged 85–89
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