Sleep disturbances in Parkinson's disease patients and management options
- PMID: 23616723
- PMCID: PMC3630958
- DOI: 10.2147/NSS.S18897
Sleep disturbances in Parkinson's disease patients and management options
Abstract
Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life. These disturbances manifest in a variety of ways; for instance, insomnia, sleep fragmentation, and excessive daytime sleepiness. Sleep-related movement disorders such as restless legs syndrome and periodic leg movements may share a common pathophysiology, and occurrence of rapid eye movement behavior disorder may predate the onset of PD or other synucleinopathies by several years. Medications for PD can have a significant impact on sleep, representing a great challenge to the treating physician. Awareness of the complex relationship between PD and sleep disorders, as well as the varied way in which sleep disturbances appear, is imperative for successful long-term management.
Keywords: Parkinson disease; REM behavior disorder; fatigue; insomnia; restless legs syndrome; sleep disorders.
Similar articles
-
Sleep disturbances in Parkinson's disease with emphasis on rapid eye movement sleep behavior disorder.Int J Neurosci. 2012 Aug;122(8):407-12. doi: 10.3109/00207454.2012.677882. Epub 2012 May 11. Int J Neurosci. 2012. PMID: 22463496
-
Management of Sleep Disturbances in Parkinson's Disease.J Parkinsons Dis. 2022;12(7):2029-2058. doi: 10.3233/JPD-212749. J Parkinsons Dis. 2022. PMID: 35938257 Free PMC article. Review.
-
Sleep Dysfunction in Parkinson's Disease.Int Rev Neurobiol. 2017;133:719-742. doi: 10.1016/bs.irn.2017.05.033. Epub 2017 Jul 10. Int Rev Neurobiol. 2017. PMID: 28802939 Review.
-
Sleep Issues in Parkinson's Disease and Their Management.Neurotherapeutics. 2020 Oct;17(4):1480-1494. doi: 10.1007/s13311-020-00938-y. Epub 2020 Oct 7. Neurotherapeutics. 2020. PMID: 33029723 Free PMC article. Review.
-
Sleep disturbances in Parkinson's disease.Curr Neurol Neurosci Rep. 2003 Mar;3(2):173-80. doi: 10.1007/s11910-003-0073-2. Curr Neurol Neurosci Rep. 2003. PMID: 12583848 Review.
Cited by
-
The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease.Mov Disord. 2016 Jan;31(1):23-38. doi: 10.1002/mds.26484. Epub 2015 Dec 30. Mov Disord. 2016. PMID: 26715466 Free PMC article. Review.
-
Rhythms of life: circadian disruption and brain disorders across the lifespan.Nat Rev Neurosci. 2019 Jan;20(1):49-65. doi: 10.1038/s41583-018-0088-y. Nat Rev Neurosci. 2019. PMID: 30459365 Free PMC article. Review.
-
Effect of zonisamide on sleep and rapid eye movement sleep behavioral disorders in patients with Parkinson's disease: A randomized control trial.Clin Park Relat Disord. 2024 Nov 22;11:100285. doi: 10.1016/j.prdoa.2024.100285. eCollection 2024. Clin Park Relat Disord. 2024. PMID: 39650051 Free PMC article.
-
Serial macro-architectural alterations with levodopa in Parkinson's disease: Polysomnography (PSG)-based analysis.Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):309-13. doi: 10.4103/0972-2327.160102. Ann Indian Acad Neurol. 2015. PMID: 26425009 Free PMC article.
-
Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson's Disease Animal Model.Mol Neurobiol. 2020 Feb;57(2):837-847. doi: 10.1007/s12035-019-01740-4. Epub 2019 Sep 6. Mol Neurobiol. 2020. PMID: 31493243
References
-
- Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature. 1997;388(6645):839–840. - PubMed
-
- Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson’s disease: a clinicopathologic study. Neurology. 1992;42(6):1142–1146. - PubMed
-
- Jellinger KA. A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta. 2009;1792(7):730–740. - PubMed
-
- Postuma RB, Gagnon JF, Montplaisir J. Autonomic dysfunction in RBD – what can it teach us about disease progression? Sleep Med. 2008;9(5):473–474. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources