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. 2013 Apr 24;3(1):11.
doi: 10.1186/2110-5820-3-11.

Acute respiratory distress syndrome: prevention and early recognition

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Acute respiratory distress syndrome: prevention and early recognition

Candelaria de Haro et al. Ann Intensive Care. .

Abstract

Acute respiratory distress syndrome (ARDS) is common in critically ill patients admitted to intensive care units (ICU). ARDS results in increased use of critical care resources and healthcare costs, yet the overall mortality associated with these conditions remains high. Research focusing on preventing ARDS and identifying patients at risk of developing ARDS is necessary to develop strategies to alter the clinical course and progression of the disease. To date, few strategies have shown clear benefits. One of the most important obstacles to preventive interventions is the difficulty of identifying patients likely to develop ARDS. Identifying patients at risk and implementing prevention strategies in this group are key factors in preventing ARDS. This review will discuss early identification of at-risk patients and the current prevention strategies.

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Figures

Figure 1
Figure 1
Multiple-hit model. A chain reaction of predisposing conditions and multiple hits (modifiers factors and treatments) in healthy lungs can develop mild, moderate or severe ARDS.
Figure 2
Figure 2
Preventive approaches to ARDS.

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References

    1. Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003;3:1027–1035. doi: 10.1164/rccm.200208-966WS. - DOI - PubMed
    1. Charles PE, Tissières P, Barbar SD, Croisier D, Dufour J, Dunn-Siegrist I, Chavanet P, Pugin J. Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide. Crit Care. 2011;3(4):R181. doi: 10.1186/cc10330. - DOI - PMC - PubMed
    1. Villar J, Cabrera N, Casula M, Flores C, Valladares F, Muros M, Blanch L, Slutsky AS, Kacmarek RM. Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model. Intensive Care Med. 2010;3(6):1049–1057. doi: 10.1007/s00134-010-1799-3. - DOI - PubMed
    1. Pavord ID, Birring SS, Berry M, Green RH, Brightling CE, Wardlaw AJ. Multiple inflammatory hits and the pathogenesis of severe airway disease. Eur Respir J. 2006;3(5):884–888. - PubMed
    1. Hudson LD, Milberg JA, Anardi D, Maunder RJ. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med. 1995;3:293–301. doi: 10.1164/ajrccm.151.2.7842182. - DOI - PubMed

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