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. 2013 Jun 5;95(1):449-57.
doi: 10.1016/j.carbpol.2013.02.046. Epub 2013 Mar 16.

β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications

Abu Zayed Md Badruddoza  1 , Md Taifur Rahman, Sudipa Ghosh, Md Zakir Hossain, Jizhong Shi, Kus Hidajat, Mohammad Shahab Uddin
Affiliations

β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications

Abu Zayed Md Badruddoza et al. Carbohydr Polym. .

Abstract

We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery.

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