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Review
. 2013 Dec;162(6):343-52.
doi: 10.1016/j.trsl.2013.04.001. Epub 2013 Apr 22.

Telomeres in lung disease

John M Gansner  1 , Ivan O Rosas
Affiliations
Review

Telomeres in lung disease

John M Gansner et al. Transl Res. 2013 Dec.

Abstract

Telomeres are DNA-protein structures that cap the ends of chromosomes; telomerase is the enzyme that ensures their integrity. Telomere biology has recently been implicated in the pathogenesis of a variety of lung diseases, including idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease/emphysema, and lung cancer. This review highlights recent discoveries pertaining to the role of telomere biology in lung disease.

Keywords: COPD; IPF; TERC; TERT; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; telomerase RNA component; telomerase reverse transcriptase.

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