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Comment
. 2013 May;123(5):1934-6.
doi: 10.1172/JCI69296. Epub 2013 Apr 24.

Where hypertension happens

Timothy L Reudelhuber  1
Affiliations
Comment

Where hypertension happens

Timothy L Reudelhuber. J Clin Invest. 2013 May.

Abstract

Essential hypertension, which accounts for 90%-95% of all cases of hypertension seen in the clinic, is also referred to as idiopathic hypertension, because we simply don't understand the cause(s). Although many theories have been advanced, in the current issue of the JCI, Gonzalez-Villalobos et al. present further evidence implicating the intrarenal renin-angiotensin system and take us one step further by proposing a mechanism underlying this pathology.

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Figures

Figure 1
Figure 1. The circulating and intrarenal RAS.
(A) Angiotensin II is produced in the circulation and can raise blood pressure by promoting vasoconstriction and increasing salt and water retention. (B) Gonzalez-Villalobos et al. (7) suggest that circulating angiotensin II stimulates an intrarenal RAS cascade and that the resulting locally produced angiotensin II causes hypertension.
See this image and copyright information in PMC

Comment on

  • The absence of intrarenal ACE protects against hypertension.
    Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. Gonzalez-Villalobos RA, et al. J Clin Invest. 2013 May;123(5):2011-23. doi: 10.1172/JCI65460. Epub 2013 Apr 24. J Clin Invest. 2013. PMID: 23619363 Free PMC article.

References

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