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. 2013 May 27;14(8):927-8.
doi: 10.1002/cbic.201300157. Epub 2013 Apr 25.

Evidence for G-quadruplex DNA in human cells

Yan Xu  1 , Makoto Komiyama
Affiliations

Evidence for G-quadruplex DNA in human cells

Yan Xu et al. Chembiochem. .

Abstract

Seen in human cells: A fluorochrome-labeled antibody probe selectively and efficiently binds all types of DNA G-quadruplex with similar binding affinities, but hardly binds single- or double-stranded DNA, or RNA hairpins. Thus, this antibody strictly discriminates between G-quadruplex structures and other conformations of DNA and provides evidence for G-quadruplex DNA in human cells.

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