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. 2013 Jul;88(7):606-11.
doi: 10.1002/ajh.23463. Epub 2013 May 30.

Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma

Yingtai Chen  1 , Tongzhang Zheng, Qing Lan, Christopher Kim, Qin Qin, Francine Foss, Xuezhong Chen, Theodore Holford, Brian Leaderer, Peter Boyle, Chengfeng Wang, Min Dai, Zhenjiang Liu, Shuangge Ma, Stephen J Chanock, Nathaniel Rothman, Yawei Zhang
Affiliations

Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma

Yingtai Chen et al. Am J Hematol. 2013 Jul.

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

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References

    1. Radak Z, Kaneko T, Tahara S, et al. The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med. 1999;27:69–74. - PubMed
    1. Radak Z, Taylor AW, Ohno H, et al. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev. 2001;7:90–107. - PubMed
    1. Sato Y, Nanri H, Ohta M, et al. Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects. Biochem Biophys Res Commun. 2003;305:333–338. - PubMed
    1. Radak Z, Naito H, Kaneko T, et al. Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch. 2002;445:273–278. - PubMed
    1. Radak Z, Gaal D, Taylor AW, et al. Attenuation of the development of murine solid leukemia tumor by physical exercise. Antioxid Redox Signal. 2002;4:213–219. - PubMed

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