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. 2013 Apr 26;340(6131):440-1.
doi: 10.1126/science.1238522.

Molecular biology. A circuitous route to noncoding RNA

Jeremy E Wilusz  1 , Phillip A Sharp
Affiliations

Molecular biology. A circuitous route to noncoding RNA

Jeremy E Wilusz et al. Science. .
No abstract available

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Figures

None
Circular RNAs sequester microRNAs
Noncoding introns [flanked by splice sites (ss)] are removed from premRNA by the splicing machinery and a poly(A) tail is added to prevent mRNA degradation (left). Linear mRNA is then translated by ribosomes unless it becomes bound by microRNAs that are associated with argonaute (Ago) protein. The latter interaction inhibits translation and/or promotes mRNA degradation. The splicing machinery can also “backsplice” and generate circular RNAs whose 5′ and 3′ ends are covalently linked (right). Large numbers of these circular RNAs sequester microRNAs from binding mRNA targets.
See this image and copyright information in PMC

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