The number of circulating CD14(+) cells is related to infarct size and postinfarct volumes in ST segment elevation myocardial infarction but not non-ST segment elevation myocardial infarction

Abstract

Objective: To determine the relationship between the number of CD14(+) cells, myocardial infarct (MI) size and left ventricular (LV) volumes in ST segment elevation MI (STEMI) and non-ST segment elevation MI (NSTEMI) patients.

Methods: A total of 62 patients with STEMI (n=34) or NSTEMI (n=28) were enrolled. The number of CD14(+) cells was assessed at admission. Infarct size, left ventricular ejection fraction (LVEF) and LV volumes were measured using magnetic resonance imaging five days after MI and six months after MI.

Results: In STEMI patients, the number of CD14(+) cells was positively and significantly correlated with infarct size at day 5 (r=0.40; P=0.016) and after six months (r=0.34; P=0.047), negatively correlated with LVEF at day 5 (r=-0.50; P=0.002) and after six months (r=-0.46; P=0.005) and positively correlated with end-diastolic (r=0.38; P=0.02) and end-systolic (r=0.49; P=0.002) volumes after six months. In NSTEMI patients, no significant correlation was found between the number of CD14(+) cells and infarct size, LVEF or LV volumes at day 5 or after six months.

Conclusions: The number of CD14(+) cells at admission was associated with infarct size and LV remodelling in STEMI patients with large infarct size, whereas in NSTEMI patients, no relationship was observed between numbers of CD14(+) cells and LV remodelling.

Keywords: Cardiac markers; Magnetic resonancce imaging; Monocytes; Myocardial infarction; Remodelling.

Figure 1)

Flow cytometric phenotyping with a monoclonal anti-CD14 antibody. Monocytes were gated in a forward scatter (FSC) / sideward scatter (SSC) dot plot among peripheral blood mononuclear cells (A). The CD14⁺ cells were defined as monocytes expressing CD14 (B)

Figure 2)

Relationship between the number of CD14⁺ cells and infarct size at day 5 and after six months in STEMI patients (A, B) and in NSTEMI patients (C, D). STEMI ST elevation myocardial infarction; NSTEMI Non-ST elevation myocardial infarction

Figure 3)

Relationship between the number of CD14⁺ cells and left ventricular ejection fraction (LVEF), end-systolic volume (LVESV) and end-diastolic volume (LVEDV) after six months in ST segment elevation myocardial infarction (STEMI) patients (A to C) and in non-ST segment elevation myocardial infarction (NSTEMI) patients (D to F).