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Review
. 2013 Mar;3(3):232-6.
doi: 10.1016/S2221-1691(13)60057-X.

RNAi: antiviral therapy against dengue virus

Sobia Idrees  1 , Usman A Ashfaq
Affiliations
Review

RNAi: antiviral therapy against dengue virus

Sobia Idrees et al. Asian Pac J Trop Biomed. 2013 Mar.

Abstract

Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.

Keywords: Dengue haemorrhagic fever; Dengue virus; RNA interference; Small interference RNA.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. Dengue virus genome.
DENV genome encodes 10 viral proteins in the order of 5′-CprM (M)-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-3′.
Figure 2.
Figure 2.. RNAi mechanism: dsRNA is degraded by DICER resulting in siRNAs. These siRNAs associates with RISC complex, targets and cleaves complementary mRNA.
See this image and copyright information in PMC

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