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Randomized Controlled Trial
. 2013 Apr;17(2):124-8.
doi: 10.1016/j.jaapos.2012.10.025.

Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age

Graham E Quinn  1 , Velma Dobson, Bradley V Davitt, David K Wallace, Robert J Hardy, Betty Tung, Dejian Lai, William V Good; Early Treatment for Retinopathy of Prematurity Cooperative Group
Collaborators, Affiliations
Randomized Controlled Trial

Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age

Graham E Quinn et al. J AAPOS. 2013 Apr.

Abstract

Purpose: To report the prevalence of myopia and high myopia in children <6 years of age born preterm with birth weights <1251 g who developed high-risk prethreshold retinopathy of prematurity and who participated in the Early Treatment for Retinopathy of Prematurity trial.

Methods: Surviving children from the cohort of 401 participants who had developed high-risk prethreshold ROP in one or both eyes underwent cycloplegic retinoscopy at 6 and 9 months corrected age and yearly between 2 and 6 years postnatal age. Eyes were randomized to receive treatment at high-risk prethreshold ROP or conventional management with treatment only if threshold ROP developed. Myopia (spherical equivalent ≥0.25 D) or high myopia (≥5.00 D) in eyes at 4-, 5-, and 6-year examinations was reported.

Results: At ages 4, 5, and 6 years, there was no difference in the percentage of eyes with myopia (range, 64.8%-69.9%) and eyes with high myopia (range, 35.3%-39.4%) between earlier treated and conventionally managed eyes.

Conclusions: Approximately two-thirds of eyes with high-risk prethreshold ROP during the neonatal period are likely to be myopic into the preschool and early school years. In addition, the increase in the proportion of eyes with high myopia that had been observed in both earlier-treated and conventionally managed eyes between ages 6 months and 3 years does not continue between ages 3 and 6 years.

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Figures

FIG 1
FIG 1
Prevalence of myopia (A), ≥0.25 D, and high myopia (B), ≥5.00 D, at seven ages for eyes in the earlier treated (ET) and conventionally managed (CM) groups. Numbers of eyes in each group at the test ages, 6 months, 9 months, and 2, 3, 4, 5, and 6 years: ET: 283, 304, 281, 268, 262, 255, 279; CM: 272, 280, 253, 243, 239, 233, 257, respectively.
FIG 2
FIG 2
Distribution of refractive error (spherical equivalent) in ET eyes at four ages, plotted in 2 D steps, from −8.00 D to +6.00 D (n = 283 at 6 months, 262 at 4 years, 255 at 5 years, and 279 at 6 years).
See this image and copyright information in PMC

Comment in

  • There's more to ROP than ROP.
    Fielder AR. Fielder AR. J AAPOS. 2013 Apr;17(2):121-3. doi: 10.1016/j.jaapos.2013.03.009. J AAPOS. 2013. PMID: 23622443 No abstract available.

References

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    1. Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: Results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003;121:1684–1696. - PubMed
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    1. Quinn GE, Dobson V, Davitt BV, et al. Early Treatment for Retinopathy of Prematurity Cooperative Group. Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity Study: Findings to 3 years of age. Ophthalmology. 2008;115:1058–1064. - PubMed

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