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. 1990 Feb;43(2):345-54.

[Pharmacokinetics of aztreonam on hemodialysis]

[Article in Japanese]
H Nagasaka  1 , O Inagaki, M Nasu, K Nakagawa, Y Nishian, K Hiraoka, T Syono, M Azuma, T Hirabayashi, H Mori, et al.
Affiliations
  • PMID: 2362356

[Pharmacokinetics of aztreonam on hemodialysis]

[Article in Japanese]
H Nagasaka et al. Jpn J Antibiot. 1990 Feb.

Abstract

We studied the pharmacokinetics of aztreonam (AZT) in 6 patients with renal insufficiencies during nonhemodialysis and hemodialysis. After intravenous injection of 1 g AZT, it was found that serum AZT concentrations during hemodialysis were different from those during nonhemodialysis and serum half-lives (T 1/2 beta) were 3.44 hours and 16.97 hours, respectively. AZT clearance changed from 0.762 L/hr during hemodialysis to 3.360 L/hr during nonhemodialysis. These findings suggest that hemodialysis patients should receive the standard dose of AZT as a loading dose, followed by one-half the loading dose per day and receive a supplemental dose equal to half their usual maintenance dose after each dialysis session.

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