Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr 26;14(5):9168-81.
doi: 10.3390/ijms14059168.

The effect of the aerial part of Lindera akoensis on lipopolysaccharides (LPS)-induced nitric oxide production in RAW264.7 cells

Chung-Ping Yang  1 , Guan-Jhong Huang, Hui-Chi Huang, Yu-Chang Chen, Chi-I Chang, Sheng-Yang Wang, Hsun-Shuo Chang, Yen-Hsueh Tseng, Shih-Chang Chien, Yueh-Hsiung Kuo
Affiliations

The effect of the aerial part of Lindera akoensis on lipopolysaccharides (LPS)-induced nitric oxide production in RAW264.7 cells

Chung-Ping Yang et al. Int J Mol Sci. .

Abstract

Four new secondary metabolites, 3α-((E)-Dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1), linderinol (6), 4'-O-methylkaempferol 3-O-α-L-(4''-E-p-coumaroyl)rhamnoside (11) and kaempferol 3-O-α-L-(4''-Z-p-coumaroyl)rhamnoside (12) with eleven known compounds-3-epilistenolide D1 (2), 3-epilistenolide D2 (3), (3Z,4α,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (4), (3E,4β,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (5), matairesinol (7), syringaresinol (8), (+)-pinoresinol (9), salicifoliol (10), 4''-p-coumaroylafzelin (13), catechin (14) and epicatechin (15)-were first isolated from the aerial part of Lindera akoensis. Their structures were determined by detailed analysis of 1D- and 2D-NMR spectroscopic data. All of the compounds isolated from Lindera akoensis showed that in vitro anti-inflammatory activity decreases the LPS-stimulated production of nitric oxide (NO) in RAW 264.7 cell, with IC50 values of 4.1-413.8 µM.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structures of 1–16.
Figure 2
Figure 2
Significant NOESY correlations (↔) of 1 and 11.
Figure 3
Figure 3
The chromatograms of 1–15 on semi-preparative HPLC.
Figure 3
Figure 3
The chromatograms of 1–15 on semi-preparative HPLC.
See this image and copyright information in PMC

References

    1. Chen C.C., Lin C.F., Huang Y.L. Bioactive constituents from the flower buds and peduncles of Lindera megaphylla. J. Nat. Prod. 1995;9:1423–1425.
    1. Chang Y.C., Chen C.Y., Chang F.R., Wu Y.C. Alkaloids from Lindera glauca. J. Chin. Chem. Soc. 2001;48:811–815.
    1. Cheng X.L., Ma S.C., Wei F., Wang G.L., Xiao X.Y., Lin R.C. A new sesquiterpene isolated from Lindera aggregata (SIMS) KOSTERM. Chem. Pharm. Bull. 2007;55:1390–1392. - PubMed
    1. Takamasa O., Akito N., Munehiro N., Makoto I., Li Y.M., Shinya M., Hajime M., Hisayoshi F. New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell cancer, SBC-3. Tetrahedron. Lett. 2005;46:8657–8660.
    1. Kouni I., Hirai A., Fukushige A., Jiang Z.H., Takashi T. New eudesmane sesquiterpenes from the root of Lindera strychnifolia. J. Nat. Prod. 2001;64:286–288. - PubMed

Publication types

LinkOut - more resources