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. 2013 Jun;20(6):766-8.
doi: 10.1038/nsmb.2569. Epub 2013 Apr 28.

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Esben M Quistgaard  1 , Christian Löw, Per Moberg, Lionel Trésaugues, Pär Nordlund
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Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Esben M Quistgaard et al. Nat Struct Mol Biol. 2013 Jun.

Abstract

Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.

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Comment in

  • This is about the in and the out.
    Henderson PJ, Baldwin SA. Henderson PJ, et al. Nat Struct Mol Biol. 2013 Jun;20(6):654-5. doi: 10.1038/nsmb.2604. Nat Struct Mol Biol. 2013. PMID: 23739167 No abstract available.

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