This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2013 Jul;10(4):286-8.

doi: 10.1038/cmi.2013.15. Epub 2013 Apr 29.

Critical role of PD-1/PD-L1 pathway in generation and function of follicular regulatory T cells

Zhi-Qing Hu¹, Wei-Hua Zhao

Affiliations

PMID: 23624877
PMCID: PMC4003206
DOI: 10.1038/cmi.2013.15

Comment

Critical role of PD-1/PD-L1 pathway in generation and function of follicular regulatory T cells

Zhi-Qing Hu et al. Cell Mol Immunol. 2013 Jul.

. 2013 Jul;10(4):286-8.

doi: 10.1038/cmi.2013.15. Epub 2013 Apr 29.

Authors

Zhi-Qing Hu¹, Wei-Hua Zhao

Affiliation

¹ Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan. zqhu@med.showa-u.ac.jp

PMID: 23624877
PMCID: PMC4003206
DOI: 10.1038/cmi.2013.15

No abstract available

PubMed Disclaimer

Figures

Figure 1
The major experimental approaches and findings which reveal the critical role of the PD-1/PD-L1 pathway in T_FR generation and function. *, T_FR-mediated suppression includes the inhibition of responder T- and B-cell proliferation, and the inhibition of IgG production. See Table 1 for the mice and antigens used. B, blood; LN, lymph nodes; MOG & NP-OVA, antigens; ND, not detected; PD-1, programmed death-1; −, no significant difference.

See this image and copyright information in PMC

Comment on

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Sage PT, Francisco LM, Carman CV, Sharpe AH. Sage PT, et al. Nat Immunol. 2013 Feb;14(2):152-61. doi: 10.1038/ni.2496. Epub 2012 Dec 16. Nat Immunol. 2013. PMID: 23242415 Free PMC article.

Similar articles

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Sage PT, Francisco LM, Carman CV, Sharpe AH. Sage PT, et al. Nat Immunol. 2013 Feb;14(2):152-61. doi: 10.1038/ni.2496. Epub 2012 Dec 16. Nat Immunol. 2013. PMID: 23242415 Free PMC article.
Increased circulating follicular regulatory T cells in Hashimoto's thyroiditis.
Zhao J, Chen Y, Xu Z, Yang W, Zhu Z, Song Y, Liu J. Zhao J, et al. Autoimmunity. 2018 Nov;51(7):345-351. doi: 10.1080/08916934.2018.1516759. Epub 2018 Oct 20. Autoimmunity. 2018. PMID: 30343599
The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome.
Fonseca VR, Romão VC, Agua-Doce A, Santos M, López-Presa D, Ferreira AC, Fonseca JE, Graca L. Fonseca VR, et al. Arthritis Rheumatol. 2018 May;70(5):774-784. doi: 10.1002/art.40424. Epub 2018 Mar 25. Arthritis Rheumatol. 2018. PMID: 29361207
Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells.
Ritvo PG, Klatzmann D. Ritvo PG, et al. Front Immunol. 2019 Feb 27;10:250. doi: 10.3389/fimmu.2019.00250. eCollection 2019. Front Immunol. 2019. PMID: 30873158 Free PMC article. Review.
Follicular helper T cells in immunity and systemic autoimmunity.
Craft JE. Craft JE. Nat Rev Rheumatol. 2012 May 1;8(6):337-47. doi: 10.1038/nrrheum.2012.58. Nat Rev Rheumatol. 2012. PMID: 22549246 Free PMC article. Review.

See all similar articles

Cited by

T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Wallin EF. Wallin EF. Transplantation. 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. Transplantation. 2018. PMID: 29757907 Free PMC article. Review.
PDL1 blockage increases fetal resorption and Tfr cells but does not affect Tfh/Tfr ratio and B-cell maturation during allogeneic pregnancy.
Zeng W, Qin S, Wang R, Zhang Y, Ma X, Tian F, Liu XR, Qin X, Liao S, Sun L, Lin Y. Zeng W, et al. Cell Death Dis. 2020 Feb 12;11(2):119. doi: 10.1038/s41419-020-2313-7. Cell Death Dis. 2020. PMID: 32051396 Free PMC article.
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases.
Zhang BX, Chen ZH, Liu Y, Zeng YJ, Li YC. Zhang BX, et al. World J Gastrointest Oncol. 2019 Dec 15;11(12):1231-1239. doi: 10.4251/wjgo.v11.i12.1231. World J Gastrointest Oncol. 2019. PMID: 31908727 Free PMC article.
Are Follicular Regulatory T Cells Involved in Autoimmune Diseases?
Gong Y, Tong J, Wang S. Gong Y, et al. Front Immunol. 2017 Dec 11;8:1790. doi: 10.3389/fimmu.2017.01790. eCollection 2017. Front Immunol. 2017. PMID: 29312316 Free PMC article. Review.
Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro.
Zhu YP, Yue F, He Y, Li P, Yang Y, Han YT, Zhang YF, Sun GP, Guo DG, Yin M, Wang XN. Zhu YP, et al. Can J Vet Res. 2017 Apr;81(2):147-154. Can J Vet Res. 2017. PMID: 28408783 Free PMC article.

See all "Cited by" articles

References

1. Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol. 2013;14:152–161. - PMC - PubMed
1. Crotty S. Follicular helper CD4 T cells (TFH) Annu Rev Immunol. 2011;29:621–663. - PubMed
1. Nutt SL, Tarlinton DM. Germinal center B and follicular helper T cells: siblings, cousins or just good friends. Nat Immunol. 2011;12:472–477. - PubMed
1. Ramiscal RR, Vinuesa CG. T-cell subsets in the germinal center. Immunol Rev. 2013;252:146–155. - PubMed
1. Vinuesa CG, Linterman MA, Goodnow CC, Randall KL. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol Rev. 2010;237:72–89. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program