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. 1990 May-Jun;11(3):169-73.
doi: 10.1016/0197-4580(90)90542-8.

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

E Mullaart  1 , M E Boerrigter, R Ravid, D F Swaab, J Vijg
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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

E Mullaart et al. Neurobiol Aging. 1990 May-Jun.

Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

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