Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Apr 10;3(1):34-9.
doi: 10.1159/000350903. Print 2013 Jan.

Secondary membranous nephropathy associated with guillain-barré syndrome

Edward J Filippone  1 , Mitul Kanzaria, Rodney Bell, Eric Newman, John L Farber
Affiliations
Case Reports

Secondary membranous nephropathy associated with guillain-barré syndrome

Edward J Filippone et al. Case Rep Nephrol Urol. .

Abstract

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome (NS) in adults. It may be primary, usually mediated by IgG4 anti-phospholipase A2 autoantibodies or secondary to various other conditions. Guillain- Barré syndrome (GBS) has been associated with MN, but a cause and effect relation has not been proven. We present a case of concurrent development of GBS and severe NS, with renal biopsy demonstrating MN. IgG4 stain was negative, indicating that most likely, the MN was secondary and probably caused by the underlying GBS.

Keywords: Guillain-Barré syndrome; Membranous nephropathy; Nephrotic syndrome.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Photomicrograph of a representative glomerulus from the renal biopsy. The glomerular basement membranes are thickened prominently and uniformly without evidence of cellular proliferation. Magnification, ×40.
Fig. 2
Fig. 2
Electron micrograph of a representative glomerulus from the renal biopsy. Subepithelial and intramembranous deposits are uniformly present throughout the glomerular basement membranes. Magnification, ×2,700.
See this image and copyright information in PMC

References

    1. Haas M, Meehan SM, Karrison TG, Spargo BH. Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976–1979 and 1995–1997. Am J Kidney Dis. 1997;30:621–631. - PubMed
    1. Swaminathan S, Leung N, Lager DJ, et al. Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study. Clin J Am Soc Nephrol. 2006;1:483–487. - PubMed
    1. Beck LH, Jr, Bonegio RGB, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009;361:11–21. - PMC - PubMed
    1. Fervenza FC, Sethi S, Specks U. Idiopathic membranous nephropathy: diagnosis and treatment. Clin J Am Soc Nephrol. 2008;3:905–919. - PubMed
    1. Lai KN, Li PKT, Lui SF, et al. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med. 1991;324:1457–1463. - PubMed

Publication types

LinkOut - more resources