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Case Reports
. 2013 Jun 15;259(1-2):88-91.
doi: 10.1016/j.jneuroim.2013.04.004. Epub 2013 Apr 28.

GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis

Affiliations
Case Reports

GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis

S Mundiyanapurath et al. J Neuroimmunol. .

Abstract

Background: Gamma-aminobutyric-acid B (GABA-B)-receptor encephalitis represents a novel entity among autoimmune CNS disorders. Most cases are characterised by limbic encephalitis.

Case report: A 63-year-old patient presented with acute vertigo, nausea and vomiting, facial palsy and dysarthria. He developed dysphagia, gait ataxia and, finally, respiratory failure. Antibodies to GABA-B receptors were positive and declined under treatment with intravenous methylprednisolone and plasma exchange, followed by clinical improvement and stabilisation. Broad tumour screening revealed oesophageal carcinoma.

Conclusion: The spectrum of neurological manifestations and tumours associated with the paraneoplastic variant of anti-GABA-B-receptor encephalitis may be broader than previously reported.

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