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Randomized Controlled Trial
. 2013 May;95-B(5):629-35.
doi: 10.1302/0301-620X.95B5.30406.

Analgesia after total knee replacement: local infiltration versus epidural combined with a femoral nerve blockade: a prospective, randomised pragmatic trial

J T Yadeau  1 , E A Goytizolo, D E Padgett, S S Liu, D J Mayman, A S Ranawat, M C Rade, G H Westrich
Affiliations
Randomized Controlled Trial

Analgesia after total knee replacement: local infiltration versus epidural combined with a femoral nerve blockade: a prospective, randomised pragmatic trial

J T Yadeau et al. Bone Joint J. 2013 May.

Abstract

In a randomised controlled pragmatic trial we investigated whether local infiltration analgesia would result in earlier readiness for discharge from hospital after total knee replacement (TKR) than patient-controlled epidural analgesia (PCEA) plus femoral nerve block. A total of 45 patients with a mean age of 65 years (49 to 81) received a local infiltration with a peri-articular injection of bupivacaine, morphine and methylprednisolone, as well as adjuvant analgesics. In 45 PCEA+femoral nerve blockade patients with a mean age of 67 years (50 to 84), analgesia included a bupivacaine nerve block, bupivacaine/hydromorphone PCEA, and adjuvant analgesics. The mean time until ready for discharge was 3.2 days (1 to 14) in the local infiltration group and 3.2 days (1.8 to 7.0) in the PCEA+femoral nerve blockade group. The mean pain scores for patients receiving local infiltration were higher when walking (p = 0.0084), but there were no statistically significant differences at rest. The mean opioid consumption was higher in those receiving local infiltration. The choice between these two analgesic pathways should not be made on the basis of time to discharge after surgery. Most secondary outcomes were similar, but PCEA+femoral nerve blockade patients had lower pain scores when walking and during continuous passive movement. If PCEA+femoral nerve blockade is not readily available, local infiltration provides similar length of stay and similar pain scores at rest following TKR.

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Conflict of interest statement

Conflict of Interest – No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

Figures

Figure 1
Figure 1
CONSORT Diagram. Flow of patients through the protocol (PCEA, patient-controlled epidural analgesia; FNB, femoral nerve blockade).
Figure 2
Figure 2
Kaplan-Meier survival curves of time (hours) to readiness for discharge. Time 0 = time out of the operating theatre. The dotted line represents the local infiltration group and the solid line represents the patient-controlled epidural analgesia + femoral nerve blockade group.
Figure 3
Figure 3
Kaplan-Meier survival curves of time (hours) to actual discharge. Time 0 = time out of the operating theatre. The dotted line represents the local infiltration group and the solid line represents the patient-controlled epidural analgesia + femoral nerve blockade group.
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References

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