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Comment
. 2013 May 29;32(11):1496-8.
doi: 10.1038/emboj.2013.103. Epub 2013 Apr 30.

SUMO wrestling with Drp1 at mitochondria

Caroline A Anderson  1 , Craig Blackstone
Affiliations
Comment

SUMO wrestling with Drp1 at mitochondria

Caroline A Anderson et al. EMBO J. .

Abstract

EMBO J 32 11: 1514–1528; March 22 2013; ; DOI: 10.1038/emboj.2013.65

Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Drp1 SUMO-2/3-ylation pathway. During ischaemic stress, SENP3 is degraded, prolonging Drp1 SUMOylation and shifting Drp1 localization to the cytoplasm. Reoxygenation-induced SENP3 recovery results in deSUMOylation of Drp1, with increased Drp1 localization to the mitochondria and subsequent mitochondrial fragmentation, cytochrome c (cyt c) release, and cell death. S, SUMO-2/3 modification.
See this image and copyright information in PMC

Comment on

References

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