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Comment
. 2013 May;83(5):785-7.
doi: 10.1038/ki.2013.38.

Synthetic oleanane triterpenoids: magic bullets or not?

Hanna E Abboud  1
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Free article
Comment

Synthetic oleanane triterpenoids: magic bullets or not?

Hanna E Abboud. Kidney Int. 2013 May.
Free article

Abstract

A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

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