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Case Reports
. 2012 Nov;53(11):1219-21.

Infectious canine hepatitis associated with prednisone treatment

Valerie M Wong  1 , Candace Marche, Elemir Simko
Affiliations
Case Reports

Infectious canine hepatitis associated with prednisone treatment

Valerie M Wong et al. Can Vet J. 2012 Nov.

Abstract
in English, French

An 11-week-old, female Alaskan husky dog housed outdoors in the Yukon, Canada, was diagnosed with infectious canine hepatitis. The predisposing factors in this puppy for such a rare disease included inappropriate vaccination program, potential contact with endemic wildlife, and immunosuppression due to prednisone treatment.

Hépatite canine infectieuse associée au traitement par la prednisone. Une chienne Husky d’Alaska âgée de 11 semaines logée en plein air au Yukon, au Canada, a été diagnostiquée avec l’hépatite canine infectieuse. Les facteurs prédisposants chez ce chiot pour une telle maladie rare incluaient un programme de vaccination inadéquat, le contact potentiel avec des animaux sauvages indigènes et l’immunosuppression en raison du traitement avec de la prednisone.(Traduit par Isabelle Vallières).

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Figures

Figure 1
Figure 1
Cross section of the liver shows multifocal zonal necrosis. Bar = 1 cm.
Figure 2
Figure 2
Hematoxylin & eosin-stained liver sections show hepatic necrosis, intranuclear inclusion bodies with margination of chromatin (arrows), and cholestasis (arrowheads). Bar = 50 μm.
Figure 3
Figure 3
Electron microscopy shows adenoviral particles within the nucleus.
Figure 4
Figure 4
Hepatocytes show positive nuclear staining for CAV-1. Immunohistochemical staining for CAV-1. Bar = 50 μm.
See this image and copyright information in PMC

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