Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr 25;7(4):e2081.
doi: 10.1371/journal.pntd.0002081. Print 2013.

Peripheral blood mononuclear cells of mycetoma patients react differently to Madurella mycetomatis antigens than healthy endemic controls

Ehab A M Elagab  1 , Maowia M Mukhtar, Ahmed H Fahal, Wendy W J van de Sande
Affiliations

Peripheral blood mononuclear cells of mycetoma patients react differently to Madurella mycetomatis antigens than healthy endemic controls

Ehab A M Elagab et al. PLoS Negl Trop Dis. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Cytokine concentrations of stimulated PBMCs of eumycetoma patients and healthy controls.
(A) IL-10 concentrations (pg/ml) measured after stimulating PBMCs from eumycetoma patients and healthy endemic controls with M. mycetomatis antigen. Statistically significantly different concentrations were found between eumycetoma patients and healthy controls (p = 0.004) as determined by the Mann–Whitney U test. (B) IFN-γ concentrations (pg/ml) measured after stimulating PBMCs from eumycetoma patients and healthy endemic controls with M. mycetomatis antigen. Statistically significantly different concentrations were found between eumycetoma patients and healthy controls (p = 0.007) as determined by the Mann–Whitney U test. (C) TNF-α concentrations (pg/ml) measured after stimulating PBMCs from eumycetoma patients and healthy endemic controls with M. mycetomatis antigen. No statistically significantly different concentrations were found between eumycetoma patients and healthy controls (p = 0.85) as determined by the Mann–Whitney U test. (D) TGF-β concentrations (pg/ml) measured after stimulating PBMCs from eumycetoma patients and healthy endemic controls with M. mycetomatis antigen. No statistically significantly different concentrations were found between eumycetoma patients and healthy controls (p = 0.89) as determined by the Mann–Whitney U test.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ahmed AO, van Leeuwen W, Fahal A, van de Sande WWJ, Verbrugh H, et al. (2004) Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis 4: 566–574. - PubMed
    1. de Klerk N, de Vogel C, Fahal A, van Belkum A, van de Sande WW (2012) Fructose-bisphosphate aldolase and pyruvate kinase, two novel immunogens in Madurella mycetomatis . Med Mycol 50: 143–151. - PubMed
    1. van de Sande WW, Janse DJ, Hira V, Goedhart H, van der Zee R, et al. (2006) Translationally controlled tumor protein from Madurella mycetomatis, a marker for tumorous mycetoma progression. J Immunol 177: 1997–2005. - PubMed
    1. Ahmed AO, van Vianen W, ten Kate MT, van de Sande WW, van Belkum A, et al. (2003) A murine model of Madurella mycetomatis eumycetoma. FEMS Immunol Med Microbiol 37: 29–36. - PubMed
    1. Zhang L, Mia MY, Zheng CL, Hossain MA, Yamasaki F, et al. (1999) The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. Immunology 98: 267–272. - PMC - PubMed

Publication types

LinkOut - more resources