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Comment
. 2013 May;9(5):405-8.
doi: 10.1586/eci.13.28.

Targeting IL-15 in large granular lymphocyte leukemia

Steven N Steinway  1 , Thomas P Loughran
Affiliations
Comment

Targeting IL-15 in large granular lymphocyte leukemia

Steven N Steinway et al. Expert Rev Clin Immunol. 2013 May.

Abstract

IL-15 is a cytokine that stimulates the proliferation of NK and T cells. Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ receptor, expressed on T-LGL, is explored in this trial to evaluate the safety, pharmacokinetics, specificity and clinical efficacy of Hu-Mikβ1. The study demonstrated no toxicity and favorable saturation of IL2/IL15Rβ receptor, but no clinical efficacy in this Phase I study.

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