Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 May 1:6:171.
doi: 10.1186/1756-0500-6-171.

Long-term cardiac changes in patients with systemic lupus erythematosus

Moacir Fernandes de Godoy  1 , Cibele Matsuura de Oliveira, Vanessa Alves Fabri, Luiz Carlos de Abreu, Vitor E Valenti, Adilson Casemiro Pires, Rodrigo Daminello Raimundo, José Luiz Figueiredo, Glauce Rejane Leonardi Bertazzi
Affiliations

Long-term cardiac changes in patients with systemic lupus erythematosus

Moacir Fernandes de Godoy et al. BMC Res Notes. .

Abstract

Background: The aim of this study was evaluate the late-onset repercussions of heart alterations of patients with systemic lupus erythematosus (SLE) after a 13-year follow up.

Methods: A historical prospective study was carried out involving the analysis of data from the charts of patients with a confirmed diagnosis of lupus in follow up since 1998. The 13-year evolution was systematically reviewed and tabulated to facilitate the interpretation of the data.

Results: Forty-eight patient charts were analyzed. Mean patient age was 34.5 ± 10.8 years at the time of diagnosis and 41.0 ± 10.3 years at the time of the study (45 women and 3 men). Eight deaths occurred in the follow-up period (two due to heart problems). Among the alterations found on the complementary exams, 46.2% of cases demonstrated worsening at reevaluation and four patients required a heart catheterization. In these cases, coronary angioplasty was performed due to the severity of the obstructions and one case required a further catheterization, culminating in the need for surgical myocardial revascularization.

Conclusion: The analysis demonstrated progressive heart impairment, with high rates of alterations on conventional complementary exams, including the need for angioplasty or revascularization surgery in four patients. These findings indicate the need for rigorous cardiac follow up in patients with systemic lupus erythematosus.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Survival curve of Kaplan-Meier for free of death at long term follow-up (until 13.6 years).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Alarcón-Segóvia D. The pathogenesis of immune dysregulation in systemic lupus erythematosus: a troika. J Rheumatol. 1984;11:588–590. - PubMed
    1. Horwitz DA, McCarty DJ, Koopman WJ. Arthritis and allied conditions. 12. Philadelphia: Lea & Febiger; 1993. Systemic lupus erythematosus: generalized autoimmunity arising from disordered immune regulation; pp. 185–199.
    1. Tan EM, Cohen AS, Fries JF. The 1982 revised criteria for the classification of systemic lupus erythmatosus. Arthritis Rheum. 1982;25:1271–1277. doi: 10.1002/art.1780251101. - DOI - PubMed
    1. Pina FP, Silva GJ, Martins RP, Paiva NA, Bonfiglioli R, Provenza JR. Early cardiac involvement in systemic lupus erythematosus. Rev Cienc Med. 2003;12:381–385.
    1. Libman E, Sacks B. A hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med. 1924;33:701–737. doi: 10.1001/archinte.1924.00110300044002. - DOI