Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy
- PMID: 23635960
- PMCID: PMC3716405
- DOI: 10.1212/WNL.0b013e318294b2eb
Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy
Abstract
Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is increasing recognition of clinicopathologic variants of PSP.(1.)
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