Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 May;4(5):331-41.
doi: 10.1007/s13238-013-2093-2. Epub 2013 Apr 30.

EZH2, an epigenetic driver of prostate cancer

Yeqing Angela Yang  1 , Jindan Yu
Affiliations
Free PMC article
Review

EZH2, an epigenetic driver of prostate cancer

Yeqing Angela Yang et al. Protein Cell. 2013 May.
Free PMC article

Abstract

The histone methyltransferase EZH2 has been in the limelight of the field of cancer epigenetics for a decade now since it was first discovered to exhibit an elevated expression in metastatic prostate cancer. It persists to attract much scientific attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target. Thus here we review the dysregulation of EZH2 in prostate cancer, its function, upstream regulators, downstream effectors, and current status of EZH2-targeting approaches. This review therefore provides a comprehensive overview of EZH2 in the context of prostate cancer.

PubMed Disclaimer

References

    1. Cancer. 2009 Aug 15;115(16):3670-9 - PubMed
    1. Eur J Drug Metab Pharmacokinet. 1995 Jul-Sep;20(3):197-202 - PubMed
    1. Urol Oncol. 2008 Mar-Apr;26(2):182-9 - PubMed
    1. Cancer Res. 2000 Sep 15;60(18):5165-70 - PubMed
    1. Nucleic Acids Res. 2010 Nov;38(21):7500-12 - PubMed

MeSH terms

Substances