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. 2013 Apr 18;6(2):169-73.
doi: 10.3980/j.issn.2222-3959.2013.02.12. Print 2013.

Bevacizumab vs ranibizumab for neovascular age-related macular degeneration in Chinese patients

Jun Li  1 , Han Zhang, Peng Sun, Feng Gu, Zhe-Li Liu
Affiliations

Bevacizumab vs ranibizumab for neovascular age-related macular degeneration in Chinese patients

Jun Li et al. Int J Ophthalmol. .

Abstract

Aim: To compare the clinical efficacy of intravitreal injections of bevacizumab and ranibizumab for treating Chinese patients with neovascular age-related macular degeneration (AMD).

Methods: Among 60 Chinese patients with exudative AMD (60 eyes), 28 received intravitreal bevacizumab injections (1.25mg) and 32 received intravitreal ranibizumab injections (0.5mg), once a month for 3 months and were followed for a total of 6 months. Monthly optical coherence tomography (OCT) was used to determine whether the patients received additional treatments during the follow-up. We compared the baseline and 6-month follow-up values of mean best-corrected visual acuity (BCVA) and central retinal thickness (CRT) in both groups of patients. We also compared the occurrence of adverse events.

Results: At the 6-month follow-up, the mean BCVA (logMAR) of the bevacizumab and ranibizumab treatment groups improved from the baseline measurements of 0.72±0.23 and 0.73±0.22 to 0.47±0.14 and 0.45±0.20, respectively (P<0.05 for both groups). However, the change was not significantly different between the two groups. As evaluated by OCT, CRT decreased from 366.71±34.72µm and 352±36.9µm at baseline to 250.86±41.51µm and 243.22±41.38µm in the bevacizumab and ranibizumab groups, respectively (P<0.05 for both groups). However, the change was not significantly different between the two groups. There were no severe local adverse reactions or systemic adverse events.

Conclusion: Intravitreal bevacizumab and ranibizumab have equivalent effects on BCVA and CRT and appeare safe over the short-term.

Keywords: age-related macular degeneration; bevacizumab (avastin); choroidal neovascularization; ranibizumab (lucentis).

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Figures

Figure 1
Figure 1. BCVA changes over 6 months.
Error bars represent 95% confidence interval (CI).
Figure 2
Figure 2. CRT changes over 6 months.
Error bars represent 95% confidence intervals (CI).
Figure 3
Figure 3. Incidence of adverse events.
See this image and copyright information in PMC

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