Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 May 2;13(1):14.
doi: 10.1186/1472-6890-13-14.

Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years

Liang Chen #  1 , Xiang Zou #  1 , Yin Wang  2 , Ying Mao  1 , Liangfu Zhou  1
Affiliations

Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years

Liang Chen et al. BMC Clin Pathol. .

Abstract

Background: Tumor epidemiology is a significant part of CNS (central nervous system) tumor studies. Reassessment of original sections can update our knowledge of tumor spectrum. Here, we discuss the features of CNS tumor pathology in a single center.

Methods: A total of 34140 cases from 1950 to 2009 were collected; sections from 1990 to 2009 were reassessed according to WHO 2007 classification, and cases from 1950 to 1989 were classified according to the previous pathological diagnosis.

Results: Seven CNS tumor categories during 1990 to 2009 were as follow: neuroepithelial tissue (38.0%), tumors of the meninges (36.5%), tumors of the sellar region (4.1%), germ cell tumors (1.3%), tumors of cranial and paraspinal nerves (13.3%), lymphomas and hematopoietic neoplasm (1.7%), metastatic tumors (5.1%), where histological types by age and sex were diverse. Overall, males exceeded females in distributions of most CNS tumor subtypes, while tumors of the meninges occurred more frequently in females. The case number of lymphomas and hematopoietic neoplasms grew the fastest during the past five years, and the distribution of neuroepithelial tumors remained stable over the past twenty years.

Conclusions: Despite the possibilities of cross sample biases, the data in this series could suggest a similar CNS tumor spectrum as might occur in other developing countries.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of CNS tumors by age and sex from 1990 to 2009.
Figure 2
Figure 2
Distribution of malignant tumors (WHO III-IV) by age and sex from 1990 to 2009.
Figure 3
Figure 3
Some malignant tumors in children and elders from 1990 to 2009. GBM = Glioblastoma; MT = Metastatic Tumor; MBM = Medulloblastoma; AA = Anaplastic astrocytoma; LYM = Lymphoma; GER = Germinoma; AO = Anaplastic oligodendrocytoma; AE = Anaplastic ependymoma; PNET = Primitive neuroectodermal tumor; GSM = Gliosarcoma.
Figure 4
Figure 4
Time trends from 1990 to 2009 by sex.
Figure 5
Figure 5
Growth rate of CNS tumors (90-94/05-09). I = Tumors of neuroepithelial tissue; II = Tumors of cranial and paraspinal nerves; III = Tumors of meninges; IV = Lymphomas and hematopoietic neoplasms; V = Germ cell tumors; VI = Tumors of the sellar region; VII = Metastatic tumors.
Figure 6
Figure 6
Growth Rate (05-09/90-94) of CNS tumors by WHO grade.
Figure 7
Figure 7
Growth rate of neuroepithelial tumors. N&M = Neuronal and mixed neuronal-glial tumors; CPT = Choroid plexus tumors; EMT = Embryonal tumors; ODT = Oligodendroglial tumors; OAT = Oligoastrocytic tumors; EPT = Ependymal tumors; TPR = Tumors of pineal region; AT = Astrocytic tumors.
Figure 8
Figure 8
Distribution of neuroepithelial tumors by time.
See this image and copyright information in PMC

References

    1. He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP, Klag MJ, Whelton PK. Major causes of death among men and women in China. N Engl J Med. 2005;353(11):1124–1134. doi: 10.1056/NEJMsa050467. - DOI - PubMed
    1. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide, version 2.0. IARC cancerbase no. 5. IARC: Lyon; 2004.
    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO classification of tumours of the central nervous system. Lyon: IARC; 2007. - PMC - PubMed
    1. Rousseau A, Mokhtari K, Duyckaerts C. The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol. 2008;21(6):720–727. doi: 10.1097/WCO.0b013e328312c3a7. - DOI - PubMed
    1. Rigau V, Zouaoui S, Mathieu-Daudé H, Darlix A, Maran A, Trétarre B, Bessaoud F, Bauchet F, Attaoua R, Fabbro-Peray P, Fabbro M, Kerr C, Taillandier L, Duffau H, Figarella-Branger D, Costes V, Bauchet L. French brain tumor database: 5-year histological results on 25 756 cases. Brain Pathol. 2011;21(6):633–644. doi: 10.1111/j.1750-3639.2011.00491.x. - DOI - PMC - PubMed

LinkOut - more resources