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. 2013 Jun;44(6):1732-5.
doi: 10.1161/STROKEAHA.111.000620. Epub 2013 May 2.

Rating method for dilated Virchow-Robin spaces on magnetic resonance imaging

Hieab H H Adams  1 , Margherita Cavalieri, Benjamin F J Verhaaren, Daniel Bos, Aad van der Lugt, Christian Enzinger, Meike W Vernooij, Reinhold Schmidt, M Arfan Ikram
Affiliations

Rating method for dilated Virchow-Robin spaces on magnetic resonance imaging

Hieab H H Adams et al. Stroke. 2013 Jun.

Abstract

Background and purpose: Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization.

Methods: We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability.

Results: Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels.

Conclusions: We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.

Keywords: MRI; Virchow–Robin spaces; epidemiology; population-based study.

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