Emerging Therapeutic Options for the Management of COPD
- PMID: 23641160
- PMCID: PMC3629926
- DOI: 10.4137/CCRPM.S8140
Emerging Therapeutic Options for the Management of COPD
Abstract
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is projected to be the third by 2020. COPD is characterized by chronic airflow limitation caused by airway inflammation and parenchymal destruction that is usually progressive. Inhaled bronchodilators continue to be the mainstay of the current management of COPD. Safety and efficacy data of the recently approved medications including aclidinium, glycopyrronium, roflumilast, and indacaterol are reviewed here.
Keywords: COPD therapy; chronic obstructive pulmonary disease; long-acting muscarinic agent; long-acting β2-agonist; phosphodiesterase-4 inhibitor.
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References
-
- Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of COPD (GOLD) 2013. Global Initiative for Chronic Obstructive Lung Disease. [Accessed February 18, 2013]. http://www.goldcopd.org. Updated 2013.
-
- Soriano JB, Lamprecht B. Chronic obstructive pulmonary disease: a worldwide problem. Med Clin North Am. 2012;96(4):671–80. - PubMed
-
- Seifart C, Vogelmeier C. Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009;14(1):181–94. - PubMed
-
- Casarosa P, Bouyssou T, Germeyer S, et al. Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs. J Pharmacol Exp Ther. 2009;330(2):660–8. - PubMed
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