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. 2013 Apr 12;6(4):275-81.
Print 2013.

Screening for high risk human papilloma virus (HR-HPV) subtypes, among Sudanese patients with oral lesions

Ali Yousif Babiker  1 , Faris Margani Eltom, Mohamed S Abdalaziz, Arshad Rahmani, Saadalnour Abusail, Hussain Gadelkareem Ahmed
Affiliations

Screening for high risk human papilloma virus (HR-HPV) subtypes, among Sudanese patients with oral lesions

Ali Yousif Babiker et al. Int J Clin Exp Med. .

Abstract

HR-HPV subtypes are strongly linked to etiology of many human cancers including oral cancer. The epidemiology of infection with different HPV genotypes greatly varies in different countries. The aim of this study was to identify and genotype the HR-HPV subtypes in oral tissues obtained from Sudanese patients with oral lesions. In this retrospective study 200 patients with oral lesions were screened by molecular methods (PCR) for the presence of HR-HPV subtypes. Of the 200 patients, 100/200 were patients with oral cancer (ascertained as case group) and 100/200 were patients with non-neoplastic oral lesions (ascertained as control group). Out of the 200 patients, 12/200 (6%) were found with HR-HPV infection. Of the 12 positive patients, 8/12 (66.7%) were among cases and the remaining 4/12 (33.3%) were among control group. The distribution of different genotypes was: type HPV 16 6/12 (50%), HPV18 4/12 (34%), HPV 31 1/12 (8%) and HPV 33 1/12 (8%). In view of these findings, HPV particularly subtypes 16 and 18 play a role in the etiology of oral cancer in the Sudan.

Keywords: HR- HPV; Oral lesions; PCR; Toombak; smoking.

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Figures

Figure 3
Figure 3
PCR amplification of high risk Oral lesions samples. The products were electrophoresed on 2% agarose gel and stained with ethidium bromide. Lane (N): Negative control, lane 1-, 2, 5, 6, 7.9. positive tumor samples, lane 1, 2, 5 HPV 18 positive tumor samples. Lane 3, 4, 8 negative samples. Lane 6 HPV 33. positive tumor samples. Lane 7, 9 HPV 16 positive tumor samples.
Figure 1
Figure 1
Description of the study population by age.
Figure 2
Figure 2
Distribution of the study population by oral lesions and gender.
See this image and copyright information in PMC

References

    1. Nelson L, Rhodus N. Oral cancer: Leukoplakia and squamous cell carcinoma. Dent clin N Am. 2005;49:143–165. - PubMed
    1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309–316. - PubMed
    1. Marchioni DM, Fisberg RM, De Góis Filho F. Fatores dietéticos e câncer oral: estudo casocontrole na Região Metropolitana de São Paulo, Brasil. Cadernos de Saúde Pública. 2007;23:553–564. - PubMed
    1. Ahmed HG, Mahgoob RM. Impact of Toombak dipping in the etiology of oral cancer: Gender-exclusive hazard in the Sudan. J Cancer Res Ther. 2007;3:127–130. - PubMed
    1. Scully C. Oral squamous cell carcinoma; from an hypothesis about a virus, to concern about possible sexual transmission. Oral Oncol. 2002;38:227–234. - PubMed

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