Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;37(2):113-6.
doi: 10.4093/dmj.2013.37.2.113.

Metformin and cancer in type 2 diabetes

Hyeong Kyu Park  1
Affiliations

Metformin and cancer in type 2 diabetes

Hyeong Kyu Park. Diabetes Metab J. 2013 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Effects of metformin on cancer. Metformin inhibits hepatic gluconeogenesis and stimulates glucose uptake in peripheral tissue, thereby lowering circulating insulin levels, and indirectly reducing phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling. Metformin also activates AMP-activated protein kinase (AMPK) leading to inhibition of mTOR signaling and protein synthesis in cancer cells. Metformin may directly inhibit mTOR signaling [30-32]. IR/IGF-1R, insulin receptor/insulin-like growth factor-1 receptor.
See this image and copyright information in PMC

References

    1. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Endocr Relat Cancer. 2009;16:1103–1123. - PubMed
    1. Barone BB, Yeh HC, Snyder CF, Peairs KS, Stein KB, Derr RL, Wolff AC, Brancati FL. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA. 2008;300:2754–2764. - PMC - PubMed
    1. Onitilo AA, Engel JM, Glurich I, Stankowski RV, Williams GM, Doi SA. Diabetes and cancer I: risk, survival, and implications for screening. Cancer Causes Control. 2012;23:967–981. - PMC - PubMed
    1. Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol. 2004;159:1160–1167. - PubMed
    1. Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS, Benson AB, 3rd, Fuchs CS. Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol. 2003;21:433–440. - PubMed

LinkOut - more resources