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. 2013 May 2;12(5):499-501.
doi: 10.1016/j.stem.2013.04.018.

miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells

Douglas J Winton  1
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miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells

Douglas J Winton. Cell Stem Cell. .
Free article

Abstract

Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.

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