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Review
. 2013 May;31(2):425-45.
doi: 10.1016/j.ncl.2013.02.004. Epub 2013 Mar 15.

Diabetic neuropathy part 1: overview and symmetric phenotypes

Mamatha Pasnoor  1 , Mazen M Dimachkie, Patricia Kluding, Richard J Barohn
Affiliations
Review

Diabetic neuropathy part 1: overview and symmetric phenotypes

Mamatha Pasnoor et al. Neurol Clin. 2013 May.

Abstract

Diabetes is the most common cause of neuropathy in United States and neuropathies are the most common complication of diabetes mellitus, affecting up to 50% of patients with type 1 and type 2 diabetes mellitus. Symptoms usually include numbness, tingling, pain, and weakness. Dizziness with postural changes can be seen with autonomic neuropathy. Metabolic, vascular, and immune theories have been proposed for the pathogenesis of diabetic neuropathy. Axonal damage and segmental demyelination can be seen with diabetic neuropathies. Management of diabetic neuropathy should begin at the initial diagnosis of diabetes and mainly requires tight and stable glycemic control.

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Figures

Figure 1
Figure 1
Spectrum of possible pathophysiologic causes of various diabetic neuropathies
Figure 2
Figure 2
Patient’s weight over time and the onset of neuropathic pain and initiation of diabetic therapy. +=Initiation of oral hypoglycemic; *=initiation of insulin; ↓=onset of pain
See this image and copyright information in PMC

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MeSH terms