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Case Reports
. 2013 May 2:2013:bcr2013008997.
doi: 10.1136/bcr-2013-008997.

Neuropsychiatric side effects of cyclobenzaprine

David Shprecher  1 , Colgan T Sloan, Benson Sederholm
Affiliations
Case Reports

Neuropsychiatric side effects of cyclobenzaprine

David Shprecher et al. BMJ Case Rep. .

Abstract

Cyclobenzaprine is commonly used as a muscle relaxant and analgesic. Given its tricyclic properties, serotonin syndrome is a potential side effect of this drug. We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone. Symptoms resolved within 48 h of discontinuing cyclobenzaprine. This case serves to remind clinicians to monitor for serotonin syndrome when initiating cyclobenzaprine, and when adding opiate or antidepressant medications to the regimen.

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References

    1. Reuss R, Reuter I, Jauss M, et al. Torticollis under cyclobenzaprine. Pharmacology 2009;2013:91–2 - PubMed
    1. Linden CH, Mitchiner JC, Lindzon RD, et al. Cyclobenzaprine overdosage. J Toxicol ClinToxicol 1983;2013:281–8 - PubMed
    1. O'Neil BA, Knudson GA, Bhaskara SM. First episode psychosis following cyclobenzaprine use. Can J Psychiatry 2000;2013:763–4 - PubMed
    1. Beeber AR, Manring JM., Jr Psychosis following cyclobenzaprine use. J Clin Psychiatry 1983;2013:151–2 - PubMed
    1. Gillman PK. Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity? Am J Emerg Med 2009;2013:509–10; author reply 10 - PubMed

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