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. 2007 Jul 19:2:79-84.
Print 2007.

The oncogene mcts1

Ali Hachem  1 , Suvobroto Nandi
Affiliations

The oncogene mcts1

Ali Hachem et al. Transl Oncogenomics. .

Abstract

The oncogene MCTS1, discovered as an amplified product in a subset of T-cell lymphoma lines, has been implicated in cell cycle progression and conferring a growth advantage in lymphomas and breast cancer. Recent research shows that it modulates the MAPK pathway and acts as a translational activator both in vivo and in vitro. In breast cancer cells, expression of MCTS1 confers aggressive properties and inhibits apoptosis. This article will review these data and its implications on our understanding of cancer.

Keywords: DNA damage; angiogenesis; cell cycle; oncogene; pseudogene.

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Figures

Figure 1
Figure 1
The different putative and established domains in the MCTS1 protein are shown. The gray shaded area is the Cyclin H homology domain. The tyrosine kinase (green) and the MAPK domain (double underlined) overlap by 3 amino acids. The PUA domain is single underlined and encompasses CDC2 (dark yellow) Casein Kinase II (red) and SH2 (purple).
See this image and copyright information in PMC

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