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. 2012 Dec 1;16(6):295-301.
doi: 10.1016/j.cossms.2012.10.004.

Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Bo Sun  1 , Yoon Yeo
Affiliations

Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Bo Sun et al. Curr Opin Solid State Mater Sci. .

Abstract

Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.

Keywords: Nanocrystals; nanosuspension; parenteral applications; poorly water-soluble drugs.

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Figures

Fig. 1
Fig. 1
Schematics of bottom-up and top-down production of nanocrystals. Suspensions of nanocrystals can be further processed into sterile products or other dosage forms.
Fig. 2
Fig. 2
Schematic representation of Ostwald ripening in nanosuspension.
See this image and copyright information in PMC

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