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. 2013 May;3(5):371-5.
doi: 10.1016/S2221-1691(13)60079-9.

Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

Herwandhani Putri  1 , Standie Nagadi, Yonika Arum Larasati, Nindi Wulandari, Adam Hermawan, Agung Endo Nugroho
Affiliations

Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

Herwandhani Putri et al. Asian Pac J Trop Biomed. 2013 May.

Abstract

Objective: To observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.

Methods: Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1 000 mg/kg body weight; Group IV: ChEE 1 000 mg/kg body weight; Group V: untreated (control).

Results: ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.

Conclusion: ChEE has potency to be developed as cardioprotector agent in chemotherapy.

Keywords: Cardiohepatoprotector; Chemoterapy; Citrus hystrix D.C.; Histopathology.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. Histological profil of liver sections.
A: Dox; B: Dox+ChEE 500 mg/kg body weight; C: Dox+ChEE 1 000 mg/kg body weight; D: ChEE 1 000 mg/kg body weight; E: control. Black arrows point bleeding cells, while dashed arrows point edema cells. Magnification 200×.
Figure 2.
Figure 2.. Histological profild of hearth sections.
A: Dox; B: Dox+ChEE 500 mg/kg body weight; C: Dox+ChEE 1 000 mg/kg body weight; D: ChEE 1 000 mg/kg body weight; E: control. Black arrow pointscell vacuola. Magnification 200×.
See this image and copyright information in PMC

References

    1. Krzesiński P, Wierzbowski R, Gielerak G, Hałka J, Matysiak O, Smurzyński P. Impedance cardiography in the diagnosis of capillary leak syndrome caused by doxorubicin therapy in a patient with myeloma multiplex. Cardiol J. 2010;17(1):88–91. - PubMed
    1. El-Sayyad HI, Ismail MF, Shalaby FM, Abou-El-Magd RF, Gaur RL, Fernando A, et al. et al. Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU) on the liver of male albino rats. Int J Biol Sci. 2009;5(5):466–473. - PMC - PubMed
    1. Duran I, Siu LL, Chen EX, Oza AM, Sturgeon J, Chin SF, et al. et al. Phase I trial of gemcitabine, doxorubicin and cisplatin (GAP) in patients with advanced solid tumors. Anticancer Drugs. 2006;17:81–87. - PubMed
    1. Kumar S, Marfatia R, Tannenbaum S, Yang C, Avelar E. Doxorubicin-induced cardiomyopathy 17 years after chemotherapy. Tex Heart Inst J. 2012;39(3):424–427. - PMC - PubMed
    1. Simůnek T, Stérba M, Popelová O, Adamcová M, Hrdina R, Gersl V. Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Rep. 2009;61(1):154–171. - PubMed

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