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Comparative Study
. 2013 Mar-Apr;65(2):137-41.
doi: 10.1016/j.ihj.2013.02.011. Epub 2013 Feb 21.

Comparison of diagnostic utilities of ankle-brachial index and carotid intima-media thickness as surrogate markers of significant coronary atherosclerosis in Indians

Babu Ezhumalai  1 , Subrahmanyam Dharanipragada Krishnasuri, Balachander Jayaraman
Affiliations
Comparative Study

Comparison of diagnostic utilities of ankle-brachial index and carotid intima-media thickness as surrogate markers of significant coronary atherosclerosis in Indians

Babu Ezhumalai et al. Indian Heart J. 2013 Mar-Apr.

Abstract

Aim: We aimed to compare Ankle-brachial index (ABI) and Carotid intima-media thickness (CIMT) as surrogate markers of significant coronary atherosclerosis in South Indians with coronary artery disease (CAD).

Methods and results: There were two groups: CAD group (n = 59) and Control group (n = 55). Mean ABI (0.82 ± 0.06 vs. 1.16 ± 0.11, p < 0.0001) and mean CIMT (0.74 ± 0.22 mm vs. 0.45 ± 0.09 mm, p < 0.0001) were statistically different between two groups. ABI < 0.9 (sensitivity: 91.53%, specificity: 100%) and CIMT > 0.63 mm (sensitivity: 61.02%, specificity: 98.18%) implied significant CAD. ABI and CIMT were negatively correlated to one another. With increasing severity of CAD, ABI decreased but CIMT increased.

Conclusion: ABI and CIMT are simple noninvasive tools providing insight into coronary atherosclerosis. They can be done at bedside and easily repeated than coronary angiography. ABI < 0.9 is a better surrogate marker of significant coronary atherosclerosis than CIMT > 0.63 mm in South Indians with CAD.

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Figures

Fig. 1
Fig. 1
Ankle–brachial index and severity of coronary artery disease. One-way ANOVA: F = 42.48, p < 0.0001. Posthoc test: Turkey–Kramer Multiple Comparisons test, p < 0.001.
Fig. 2
Fig. 2
Carotid intima-media thickness and severity of coronary artery disease. One-way ANOVA: F = 44.552, p < 0.0001. Posthoc test: Turkey–Kramer Multiple Comparisons test, p < 0.001.
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